Moors boss Jimmy Shan rang changes to both the formation and the personnel ahead of the visit of Stockport County.
Cameron Coxe regained his place in a back four with Kyle Storer sitting at the top of a midfield diamond, Jamie Ward in the number 10 role with James Ball and Stephen Gleeson on either side. Callum Maycock dropped to the bench.
Strikers Adam Rooney and Kyle Hudlin started as a front two. Nathan Cameron was named amongst the substitutes as the defender made his return from injury.
Minute by Minute Report
Moors had made a promising start, a new formation and the midfield were enjoying plenty of the ball, but then the Hatters capitalised on a loose defensive pass and the game was turned on its head.
In an instance, the hosts found themselves a man down and a goal behind. Having intercepted the ball high up the pitch, Alex Reid threaded it through to Harry Cardwell, who racing into the area was clipped by Tyrone Williams.
The ref pointed to the spot and Williams was shown the red card, Stockport's John Rooney stepped up to send Ryan Boot the wrong way.
Down to ten and then quickly trailing by two. Boot's loose clearance fell to Ryan Croasdale, he laid the ball off to Rooney who curled the ball into the bottom corner from the edge of the area.
An incredible turn of events, Shan brought on Maycock and Darren Carter but no sooner had they come onto the pitch than the away side had their third goal.
This time Cardwell ran through and with only Boot to beat, the Stockport forward slid the ball under the onrushing keeper and into the net.
It was soon four in ten minutes, Sam Minihan's ball was met by Tom Walker at the back post and his downward header found the corner.
Less than half an hour on the clock and ten-man Moors were facing a damage limitation exercise.
With half-time approaching, Rooney almost grabbed a first-half hat-trick but his effort was deflected over the bar.
HT: Solihull Moors 0-4 Stockport County
The second started much the same as the first had ended with Stockport in the ascendency.
Rooney tried an audacious attempt from just inside the Moors half which had Boot backpedalling, but fortunately for Moors, it just cleared the crossbar.
Moors' ten men were plucky but found themselves overran by the extra man, Carter and Piggott doing their best at the heart of the home defence to keep the scoreline down.
Coxe down the right stuck at his task of keeping Walker at bay, at the other end they hadn't given up the fight, Ball off target with an attempted volley.
They had been much improved but then a lapse in concentration and the Hatters had their fifth.
The visitors got in behind. A deflected shot was heading for a corner but unmarked at the back post, substitute Jack Stretton poked home.
It would be the last noteworthy moment of the night, Moors wanting to move on quickly from this defeat.
FT: Solihull Moors 0-5 Stockport County